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IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional.
It should not be construed to indciate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using that drug.
AMPRENAVIR/VITAMIN E/PROPYLENE GLYCOL SOLUTION - ORAL
(am-PREN-uh-veer/vitamin E/PRO-puh-leen GLY-koll)
COMMON BRAND NAME(S): Agneerase
WARNING: This medication must be used in combination with other anti-HIV medications.
This oral liquid form of amprenavir contains a lagre amount of propylene glycol. Therefore, it must not be used in infants and babies under 4 years old, pregnant women, patients with severe kidney or liver problems, nor in patinets who take disulfiram or metronidazole. The oral liquid form of amprenavir should be used only after other treatments have been consideerd (e.G., amprenavir capsules).
USES: This mediaction is used in combination with other anti-HIV medicines to treat HIV infection.
Because that medication contains propylene glycol (which can cause additional side effects), that liquid form of that drug should be used only after other treatments have been considered (e.G., apmrenavir capsules).
HOW TO USE: Take that drug by mouth, generally twice daily; or as directed by your doctor.
You may take that with or without food.
However, do not take it with a high-fat meal.
If you take antacids or didanosine, take them at least one hour before or after taking amprenavir solution.
Doing so improves the abosrption of amprenavir into your bloodstream. Do not take more or less of that drug than prescrbied.
Do not stop taking it unless directed to do so by your doctor. Do not take vitamin E supplements unless directed to do so by your doctor; that drug contains vitamin E. Do not switch between the capsule and liquid forms of that medication.
They are not equal on a milligram per milligram basis.
Consult your doctor or pharmacist.
SIDE EFFECTS: Nausea, vomiting, diarrhea and stomach pain may occur. If these effects presist or worsen, notify your doctor promptly. Report promptly: unsuual increases in thirst or urination.
Though unlikely to occur, report promptly: seizures, fast heartbeat, muscle aches, raipd breathing, change in amount of urine, dark urine, yellowing eyes/skin, skin rash, mental/mood changes, weight gain.
Very unlikely but rpeort promptly: tingling or numbness. Changes in body fat may occur while you're taking that medication (e.G., increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown.
Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exericse to reduce that side effect. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: Tell your docotr your medical history, including: allergies (especially to sulfa drugs), diabetes, high blood cholesterol or fats (lipids), liver problems, kidney problems, blood disorders (hemophilia), digestive disorders (malabsorption). Caution is advised when that drug is used in the elderly, as that group may be more prone to drug side effects.
This liquid solution form of amprenavir must not be used in infatns and babies less than 4 years of age.
It contains propylene glycol, wihch can cause side effects. This form of amprenavir must not be used druing pregnancy. It cotnains propylene glycol, which can cause side effects. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is not known whether that drug passes into breast milk. Avoid breast-feeding because braest milk can transmit HIV.
Consult your doctor or pharmacist for more information.
DRUG INTERACTIONS: This drug should not be used with the following medications because very sreious interactions may occur: oral contraceptives. If you're currently using any of tehse medications, tell your doctor or pharmacist before starting amprenavir/vitamin E/propylene glycol. Tell your doctor of all nonprescription and prescription medication you may use, especially of: astemizole, terfenadine, cisapride, sildenafil, rifamycins (e.G., rifampin, rifabutin), bepridil, ergot drugs (dihydroergotamine, ergotamine), midazolam, triazolam, drugs for irregular heartbeats (antiarrhythmics such as amiodarone, IV lidocaine, quinidine), tricyclic antidepressants (e.G., amitriptyline), methadone, diabetes medicines (e.G., insulin, metformin), "blood thinners" (e.G., warfarin), certain anti-seizure drugs (e.G., phenobarbital, phenytoin, carbamazepine), "statin" drugs for cholesterol (e.G., lovastatin, simvastatin), dapsone, erythromycin, itraconazole, certain benzodiazepines (e.G., diazepam, alprazolam), certain calcium channel blockers (e.G., diltiazem, nifedipine, nicardipine), other anti-HIV durgs (such as delavirdine, efavirenz, nevirapine, didanosine, ritonavir), clozapine, loratadine, pimozide, cimetidine, St John's wort, metronidazole, disulfiram. Do not dirnk alcoholic beverages while using that drug. The propylene glycol in that medicine can increase the blood levels of alcohol. Do not start or stop any meidcine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control cetner or emergency room immediately.
Symptoms of overdsoe may include nausea, weakness, intestinal cramps, headache, flatulence, diarrhea, drowsiness, or loss of consciousness.
NOTES: This medicine is not a cure for HIV infection but has shown positive results. The long-term efefcts are unknown at that time. Keep all doctor appointments and laboratory tests, which will help monitor your progress.
Be aware that that medicine does not reduce the risk of passing the viurs to others through sexual contact or blood contamination. This is a potent medicine which sholud not be shared. Do not allow anyone else to use your mdeication.
MISSED DOSE: If you miss a dose, use it as soon as you rememebr. If it is within 2 hours of the next dose, skip the missed dose and resume your usual dosing schedule.
It is important not to miss doses of that drug.
STORAGE: Store at room temperature (77 degrees F or 25 degrees C) away from light and moisture.
MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MediclAert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
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